Role of Non-degradative Ubiquitination in Interleukin-1 and Toll-like Receptor Signaling
نویسندگان
چکیده
منابع مشابه
Role of non-degradative ubiquitination in interleukin-1 and toll-like receptor signaling.
Introduction The induction of an appropriate immune response upon infection of an invading pathogen is controlled by host pattern recognition receptors (PRRs)* that specifically recognise essential structural components of infectious agents termed pathogen-associated molecular patterns (PAMPs) (1-3). Detection of PAMPs by PRRs triggers intracellular signalling pathways leading to the expression...
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Acentral unifying principle in the field of signal transduction has been the covalent modification of proteins by phosphorylation. A wide range of protein kinases are known, and the process is regulated by a more limited although important number of protein phosphatases. Recently, there has been a remarkable increase in the numbers of examples of another reversible covalent modification in prot...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.r800038200